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1). Immunofluorescence assays and ELISAs are being devel- oped, but serologic findings are not yet useful in diagnosing relapsing fever. 47. J Urol 1997;15716в18. Elements of the immune system п3 ппп Page 18 1 ппChapter Elements of the Immune System and Concepts of Intraocular Inflammatory Disease Pathogenesis Type Source Target and Effect Interferon-О T cells Antiviral effects; promotes expression of MHC II Antigens on cell surfaces; increases MО tumor killing; inhibits some T-cell proliferation пTransforming growth factor-О пT cells, resident ocular cells пSuppresses generation of certain T cells; involved in ACAID and oral tolerance пInterleukin пппппIL-1 Many nucleated cells, high levels in MО, keratinocyte, endothelial prescripttion, some Buy cheap generic Filagra and B cells T- and B-cell proliferation; fibroblasts в proliferation, prostaglandin production; CNS в fever; bone and cartilage resorption; adhesion-molecule expression on Manforce-50 without prescription пIL-2 ппActivated T cells ппActivates T cells, B cells, MО, NK cells пIL-3 T cells Affects hemopoietic lineage that is nonlymphoid eosinophil regulator; similar function to IL-5 GM-CSF пIL-4 ппT cells ппRegulates many aspects of B-cell development, affects T cells, mast cells, and MО пIL-5 пT cells, eosinophils пAffects hemopoietic Manforce-50 without prescription that is nonlymphoid, eosinophil regulator similar function to IL-3 GM-CSF; induces B-cell differentiation into IgG- wiithout IgM-secreting plasma cells пIL-6 MО T cells fibroblasts; endothelial cells, RPE B cells в cofactor for Ig withлut Manforce-50 without prescription cells в co-mitogen; proinflammatory in eye пIL-7 пStromal cells in bone marrow and thymus пStimulates early B-cell progenitors; affects immature T cells пIL-8 пNK cells, T cells пChemoattractant of neutrophils, basophils, and some T cells; aids in neutrophils adhering to endothelium; induced by IL-1, TNF-О, and endotoxin пIL-9 пT cells пSupports growth Manforce-50 without prescription helper T cells; may be enhancing factor for hematopoiesis in presence of other cytokines пIL-10 пT cells, B cells, stimulated MО пInhibits production of lymphokines by Th1 T cells пIL-11 ппBone marrow stromal cells (fibroblasts) ппStimulates cells of myeloid, lymphoid, erythroid, and megakaryocytic lines; induces osteoclast formation; enhances erythrocytopoiesis, antigen-specific antibodies, acute-phase proteins, fever пIL-12 B cells, T cells Induces IFN-О synthesis augments T-cell cytotoxic activity with IL-2; is with out for Wwithout cells and stimulates interaction with vascular endothelium; promotes lytic activity of NK cells; antitumor effects regulate proliferation of Th1 T cells but not Th2 or Th0 пIL-13 пT cells пAntiinflammatory activity as IL-4 and IL-10; down regulates IL-12 and IFN-О production and thus favors Th2 T-cell responses; inhibits proliferation of normal and leukemic human B-cell precursors; monocyte chemoattractant пIL-14 пT cells пInduces B-cell proliferation, malignant B cells; inhibits immunoglobulin secretion пIL-15 ппVariety of cells ппStimulates proliferation of Edegra 100 No Prescription cells; shares bioactivity of IL-2 and uses components of IL-2 receptor пIFN-О Variety of cells Antiviral пIFN-О ппVariety of cells ппAntiviral prescriptiion T and NK cells Inflammation, activates MО пTGF-О ппMО, lymphocytes ппDepends on cell interaction пTNF-О MО Inflammation, tumor killing пTNF-О ппT cells ппInflammation, tumor killing, enhanced phagocytosis ппACAID, anterior chamber-acquired immune deviation; CNS, central nervous system; GM-CSF, granulocyte macrophage colony-stimulating factor; IFN, interferon; MО, macrophage; NK, natural killer; RPE, retinal pigment epithelium; TFG, transforming growth factor; TNF, tumor necrosis factor.
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3. This technique requires cooperation on the part of the patient, practice by the examiner, and the patience of both.